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Grain Brain

September 17, 2012
by David Perlmutter, MD, FACN, ABIHM
Power Up Your Brain
Power Up Your Brain
by David Perlmutter, MD, FACN, ABIHM &
Albert Villoldo, Ph.D
Raise a Smarter Child by Kindergarten
Raise a Smarter Child by Kindergarten
by David Perlmutter, MD, FACN, ABIHM
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by David Perlmutter, MD, FACN, ABIHM
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Statins – Powerful Risk Factor for Diabetes

May 15th, 2012

I lend my voice to the countless others in raising the alarm about the epidemic of type 2 diabetes in America. Here are the sobering facts:

• There are now more than 24 million type 2 diabetics in America
• Incredibly, about 6 million of these folks don’t know they have the disease
• More than 2,000 people are diagnosed each day
• It is directly related to about 200,000 deaths yearly
• Having the disease reduces life expectancy by an incredible 15 years
• The disease increases risk of amputation by 4,000 per cent
• It doubles the risk of heart disease and stroke

From my perspective as a Neurologist and practitioner of Functional Medicine, two other points need to be made. First, type 2 diabetes is almost completely preventable. Without a doubt, lifestyle choices, including the foods we choose and the exercise we either do or don’t get, virtually dictate whether or not we will be dealing with this disease. Second, being diabetic is a robust indicator for high risk for developing Alzheimer’s disease. And bear in mind that Alzheimer’s is a disease for which we have no meaningful medical treatment whatsoever. While you may be taken in by the television ads shown on the evening news for this or that “Alzheimer’s drug,” the reality is that again, there is no pharmaceutical agent that shows any meaningful significance in treating this disease, much less offering up a cure.

In light of the powerful relationship between type 2 diabetes and Alzheimer’s, and in recognition that diabetes is preventable, its important to look at those factors that can increase a person’s risk for the former. No doubt the relationship of diabetes to diet, exercise, and therefore obesity is now pretty much common knowledge. So, putting that aside, let’s consider medications. That is, could a commonly used drug increase a person’s risk for becoming a diabetic, a disease costing American’s close to $10 billion each year?

Recently, in the highly respected medical journal, Archives of Internal Medicine, published by the American Medical Association, researchers evaluated the risk for developing diabetes in more than 160,000 subjects at 40 clinical centers around the United States over a five-year period. Their findings revealed an astounding 71% increased risk of developing diabetes in those subjects who were taking statin medications to lower their cholesterol. That is, the most commonly prescribed drug on the planet is associated with a dramatic increased risk for one of the most common diseases of our society. And keep in mind that diabetes, to most physicians, is simply a call for more pharmaceuticals. Who wins in this scenario?

What’s more, in an editorial following the study, Kirsten L. Johansen, MD, Deputy Editor of the journal, while discussing the risk of diabetes induced by these drugs called attention to the ever increasing body of research showing that risk of death in people taking statin drugs is not reduced in any way. But isn’t that why people take these drugs, to keep from dying?

The doctrines of every mainstream as well as integrative medical institution’s approach to reduce a person’s risk of developing or even treating high cholesterol first center on diet and lifestyle, not simply choosing a medication. This approach is now bolstered by the fact that peer-reviewed, scientific research now clearly links statin medication use to a dramatic increased risk for developing diabetes. We cannot afford to remain myopic in how we look at preventive medicine by simply focusing on drugs, especially when we know that certain drugs may actually contribute to the very diseases we are trying to prevent.

Remember. Above all, do no harm.

Eggs For Breakfast: A bad yolk?

March 15th, 2012

By Austin Perlmutter

 

When I tell someone that I eat four eggs each morning, the response is usually the same. First, they ask; “with the yolk?” and when I confirm “yes,” they ask me if I am worried about my cholesterol. Of course, we all know that eggs happen to be particularly rich in cholesterol. It makes sense, in a country where 24 million of us are on statin drugs, that we would be conscious of overdoing our dietary cholesterol input 1. But saying that eggs raise “cholesterol” is an oversimplification of a more complicated topic.

As we all learned in biochemistry, the key players in the cholesterol problem are HDL, VLDL, and LDL, with the main idea that we want a high HDL and a low LDL. If we are concerned about raising our cholesterol due to diet, we’d be talking about an increase in LDL, and specifically, small LDL, which has the nasty habit of embedding into arterial walls and promoting heart disease.

So what happens when you eat eggs? The famous longitudinal Framingham study found in 1982 that “differences in egg consumption were unrelated to blood cholesterol level” 2. Harvard researchers found the same results in 1999, and Japanese investigators replicated these findings in 2006 3,4. In addition, research has supported the fact that egg consumption, in conjunction with a carbohydrate-restricted diet, can raise HDL levels, as well as promoting a shift from small LDL to large LDL5, 6. Based on this information, the research suggests that people gain “no risk in developing coronary heart disease by increasing their intake of cholesterol but in contrast, they may have multiple beneficial effects by the inclusion of eggs in their regular diet” 5.

What does all this mean? Maybe we should reconsider the idea of the egg. First off, the yolk contains all the essential fatty acids, the carotenoids, and fat soluble vitamins in the egg, as well as the majority of the other nutrients. By avoiding the yolk and eating egg whites, we are throwing away the most valuable part. Second, eating eggs is not going to plunge us into a fight with coronary heart disease, raising our cholesterol and clogging our arteries. We should respect the egg as a healthy dietary choice, and a good alternative to carbohydrate-rich breakfasts.

 

References:

 

 

1. Rodine RJ, Tibbles AC, Kim PS, Alikhan N. Statin induced myopathy presenting as mechanical musculoskeletal pain observed in two chiropractic patients. J Can Chiropr Assoc. 2010 Mar;54(1):43-51. PubMed PMID: 20195425; PubMed Central PMCID: PMC2829685.

 

2. Dawber TR, Nickerson RJ, Brand FN, Pool J. Eggs, serum cholesterol, and coronary heart disease. Am J Clin Nutr. 1982 Oct;36(4):617-25. PubMed PMID: 7124663.

 

3.   Hu FB, Stampfer MJ, Rimm EB, Manson JE, Ascherio A, Colditz GA, Rosner BA, Spiegelman D, Speizer FE, Sacks FM, Hennekens CH, Willett WC. A prospective study of egg consumption and risk of cardiovascular disease in men and women. JAMA. 1999 Apr 21;281(15):1387-94. PubMed PMID: 10217054.

 

4. Nakamura Y, Iso H, Kita Y, Ueshima H, Okada K, Konishi M, Inoue M, Tsugane S. Egg consumption, serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based prospective study. Br J Nutr. 2006 Nov;96(5):921-8. PubMed PMID: 17092383.

 

 

5. Dawber TR, Nickerson RJ, Brand FN, Pool J. Eggs, serum cholesterol, and coronary heart disease. Am J Clin Nutr. 1982 Oct;36(4):617-25. PubMed PMID: 7124663.

 

6. Fernandez ML. Effects of eggs on plasma lipoproteins in healthy populations. Food Funct. 2010 Nov;1(2):156-60. Epub 2010 Oct 19. Review. PubMed PMID: 21776466.

 

Power Up Your Brain – in Polish

January 2nd, 2012

Power Up Your Brain is now available in Polish.

The Brain and Nutrition – Dr. Perlmutter Video

December 14th, 2011

The Brain and Nutrition – Dr. Perlmutter Video

ENJOY LIFE NOW

December 10th, 2011

This is a story of an aging couple
Told by their son who was President of NBC NEWS.*

This is a wonderful piece by Michael Gartner, editor of newspapers large and small and president of NBC News. In 1997, he won the Pulitzer Prize for editorial writing. It is well worth reading, and a few good chuckles are guaranteed. Here goes…

My father never drove a car. Well, that’s not quite right. I should say I never saw him drive a car.
He quit driving in 1927, when he was 25 years old, and the last car he drove was a 1926 Whippet.
“In those days,” he told me when he was in his 90s, “to drive a car you had to do things with your hands, and do things with your feet, and look every which way, and I decided you could walk through life and enjoy it or drive through life and miss it.”
At which point my mother, a sometimes salty Irishwoman, chimed in: “Oh, bull shit!” she said. “He hit a horse.” “Well,” my father said, “there was that, too.”

So my brother and I grew up in a household without a car. The neighbors all had cars — the Kollingses next door had a green 1941Dodge, the VanLaninghams across the street a gray 1936 Plymouth, the Hopsons two doors down a black 1941 Ford — but we had none.

My father, a newspaperman in Des Moines , would take the streetcar to work and, often as not, walk the 3 miles home. If he took the streetcar home, my mother and brother and I would walk the three blocks to the streetcar stop, meet him and walk home together.

My brother, David, was born in 1935, and I was born in 1938, and sometimes, at dinner, we’d ask how come all the neighbors had cars but we had none. “No one in the family drives,” my mother would explain, and that was that.

But, sometimes, my father would say, “But as soon as one of you boys turns 16, we’ll get one.” It was as if he wasn’t sure which one of us would turn 16 first.

But, sure enough, my brother turned 16 before I did, so in 1951 my parents bought a used 1950 Chevrolet from a friend who ran the parts department at a Chevy dealership downtown.

It was a four-door, white model, stick shift, fender skirts, loaded with everything, and, since my parents didn’t drive, it more or less became my brother’s car.

Having a car but not being able to drive didn’t bother my father, but it didn’t make sense to my mother.

So in 1952, when she was 43 years old, she asked a friend to teach her to drive. She learned in a nearby cemetery, the place where I learned to drive the following year and where, a generation later, I took my two sons to practice driving. The cemetery probably was my father’s idea. “Who can your mother hurt in the cemetery?” I remember him saying more than once.

For the next 45 years or so, until she was 90, my mother was the driver in the family. Neither she nor my father had any sense of direction, but he loaded up on maps — though they seldom left the city limits — and appointed himself navigator. It seemed to work.

Still, they both continued to walk a lot. My mother was a devout Catholic, and my father an equally devout agnostic, an arrangement that didn’t seem to bother either of them through their 75 years of marriage.

(Yes, 75 years, and they were deeply in love the entire time.)

He retired when he was 70, and nearly every morning for the next 20 years or so, he would walk with her the mile to St. Augustin’s Church. She would walk down and sit in the front pew, and he would wait in the back until he saw which of the parish’s two priests was on duty that morning. If it was the pastor, my father then would go out and take a 2-mile walk, meeting my mother at the end of the service and walking her home.

If it was the assistant pastor, he’d take just a 1-mile walk and then head back to the church. He called the priests “Father Fast” and “Father Slow.”

After he retired, my father almost always accompanied my mother whenever she drove anywhere, even if he had no reason to go along. If she were going to the beauty parlor, he’d sit in the car and read, or go take a stroll or, if it was summer, have her keep the engine running so he could listen to the Cubs game on the radio. In the evening, then, when I’d stop by, he’d explain: “The Cubs lost again. The millionaire on second base made a bad throw to the millionaire on first base, so the multimillionaire on third base scored.”

If she were going to the grocery store, he would go along to carry the bags out — and to make sure she loaded up on ice cream. As I said, he was always the navigator, and once, when he was 95 and she was 88 and still driving, he said to me, “Do you want to know the secret of a long life?”

“I guess so,” I said, knowing it probably would be something bizarre.

“No left turns,” he said.

“What?” I asked.

“No left turns,” he repeated. “Several years ago, your mother and I read an article that said most accidents that old people are in happen when they turn left in front of oncoming traffic.

As you get older, your eyesight worsens, and you can lose your depth perception, it said. So your mother and I decided never again to make a left turn.”

“What?” I said again.

“No left turns,” he said. “Think about it. Three rights are the same as a left, and that’s a lot safer. So we always make three rights.”

“You’re kidding!” I said, and I turned to my mother for support. “No,” she said, “your father is right. We make three rights. It works.” But then she added: “Except when your father loses count.”

I was driving at the time, and I almost drove off the road as I started laughing.

“Loses count?” I asked.

“Yes,” my father admitted, “that sometimes happens. But it’s not a problem. You just make seven rights, and you’re okay again.”

I couldn’t resist. “Do you ever go for 11?” I asked.

“No,” he said ” If we miss it at seven, we just come home and call it a bad day. Besides, nothing in life is so important it can’t be put off another day or another week.”
My mother was never in an accident, but one evening she handed me her car keys and said she had decided to quit driving. That was in 1999, when she was 90.

She lived four more years, until 2003. My father died the next year, at 102.

They both died in the bungalow they had moved into in 1937 and bought a few years later for $3,000. (Sixty years later, my brother and I paid $8,000 to have a shower put in the tiny bathroom — the house had never had one. My father would have died then and there if he knew the shower cost nearly three times what he paid for the house.)

He continued to walk daily — he had me get him a treadmill when he was 101 because he was afraid he’d fall on the icy sidewalks but wanted to keep exercising — and he was of sound mind and sound body until the moment he died

One September afternoon in 2004, he and my son went with me when I had to give a talk in a neighboring town, and it was clear to all three of us that he was wearing out, though we had the usual wide-ranging conversation about politics and newspapers and things in the news.

A few weeks earlier, he had told my son, “You know, Mike, the first hundred years are a lot easier than the second hundred.” At one point in our drive that Saturday, he said, “You know, I’m probably not going to live much longer.”

“You’re probably right,” I said.

“Why would you say that?” He countered, somewhat irritated.

“Because you’re 102 years old,” I said..

“Yes,” he said, “you’re right.” He stayed in bed all the next day.

That night, I suggested to my son and daughter that we sit up with him through the night.

He appreciated it, he said, though at one point, apparently seeing us look gloomy, he said: “I would like to make an announcement. No one in this room is dead yet”

An hour or so later, he spoke his last words:

“I want you to know,” he said, clearly and lucidly, “that I am in no pain. I am very comfortable. And I have had as happy a life as anyone on this earth could ever have.”

A short time later, he died.

I miss him a lot, and I think about him a lot. I’ve wondered now and then how it was that my family and I were so lucky that he lived so long.

I can’t figure out if it was because he walked through life, Or because he quit taking left turns. ”

Life is too short to wake up with regrets.

So love the people who treat you right.

Forget about the one’s who don’t.

Believe everything happens for a reason.

If you get a chance, take it & if it changes your life, let it.

Nobody said life would be easy, they just promised it would most likely be worth it.”
ENJOY LIFE NOW – IT HAS AN EXPIRATION DATE