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Zen in their bedside manner

June 20th, 2009

From LATimes.com:

Reporting from New York — It was 8 a.m., and the subject was death.

A 55-year-old man was wasting away from lungcancer and cirrhosis. His weight was plummeting and his brain was swelling. But he was in denial, refusing to discuss hospice care or consider a “do not resuscitate” order.

A bright pink vase filled with yellow mums sat near the window, belying the grim task facing the healthcare workers at Beth Israel Medical Center who had clustered around a conference table.

“This has been really sad,” said the Rev. Robert Chodo Campbell, a large man with thick brows who was wearing what appeared to be a cross between a judo outfit and hospital scrubs. He told the group that when faced with a similar case in the past, he had decided to disclose his personal battle with alcoholism to the patient — also an alcoholic — in hopes of spurring a conversation that might help ease the man’s mental anguish and prepare him for whatever lay ahead.

“Is that a good technique?” asked a doctor, sounding slightly incredulous.

A psychologist interjected. “In this case, it could have been a gift,” she said. “Psychologists don’t disclose anything. Chaplains operate under a different set of rules.”

And Chodo operates under a different set of rules than most chaplains as he spreads the spirit of Buddhism through the halls of Beth Israel, a 1,368-bed medical center in Manhattan. “If it seems appropriate in the moment and one is sure of one’s motives — the well-being of the patient — then why not?” the Zen chaplain asked.

According to the American Hospital Assn., about 68% of public hospitals have a chaplaincy program. But few have Buddhist monks, and none compares with the program at Beth Israel — where more than 20 Buddhist chaplains and chaplains-in-training offer bedside meditation, interdenominational prayers and other assistance to pregnant women, dying cancer patients and even stressed hospital workers.

“There is one rabbi and two Catholic priests. They’re great people, but the rabbi sees Jewish patients. The Catholics anoint the sick. Then there’s everybody else,” said the Rev. Koshin Paley Ellison, co-founder with Chodo of the New York Zen Center for Contemplative Care.

Last year, Chodo and Koshin began bringing students into the hospital as part of the country’s first Buddhist chaplaincy training program accredited by the . “We’re really trying to create a cultural shift,” said Koshin, who like Chodo uses the name given him when he took his vows to become a Buddhist priest.

Advocates say the availability of alternative treatments is crucial at a time when millions of Americans are struggling to pay for healthcare. Instead of relying on drugs and hospitalization, the Zen center encourages stress- and pain-relief through meditation, breathing exercises or simple conversation. Even if such methods cannot provide a cure, they can make patients more comfortable. And the Zen chaplains are able to spend more time with patients, time that busy doctors and nurses often cannot spare.

“We focus on listening,” said Bob Allen, a chaplaincy student who has spent much of his training time on Beth Israel’s oncology floor.

Not everyone, however, has welcomed him.

“I just started eating!” Allen recalled one patient yelling when he entered his room on a recent day. “I’m Jewish! Get out!”

In the tranquil manner that is pervasive among the Buddhist chaplains, Allen put a rosy spin on the patient’s reaction. For someone facing death, throwing an unwanted visitor out of the room “can be empowering,” Allen said. So if it made the sick man feel better about his situation, that’s a good thing.

Some doctors too are skeptical about so-called integrative medicine, the melding of alternative care with traditional Western medicine.

Teaching relaxation and pain management is good, said Dr. Bruce Flamm, an obstetrician-gynecologist at Kaiser Permanente in Riverside, who has been an outspoken critic of studies suggesting prayer and spiritualism can heal the sick. But, he said, encouraging patients to pursue “kooky” approaches with no scientifically proven benefits would be a problem.

Flamm said integrative medicine programs reflected the competitive nature of the healthcare industry. Some mainstream medical centers, he said, have introduced alternative approaches in hopes of “trying to recapture some of those patients that are veering off.”

“You can get your chemotherapy . . . and also get your acupuncture and therapeutic touch and reiki healing,” Flamm said, drawing a picture of one-stop shopping for the ill. “The question is, is that really ethical?”

Beth Israel’s Zen chaplains say they are careful in approaching patients and would never dream of countermanding a doctor’s advice. But their differing approaches are clear.

During one meeting at Beth Israel, Koshin suggested that a severely diabetic 63-year-old woman who refused insulin might benefit from a visit to the alternative-care facility that is affiliated with the hospital and offers treatments such as herbal medicine and leeching.

A doctor disagreed. “She needs really good medical care to get her diabetes under control,” the physician said.

So Koshin gently pushed his own theory that the woman might become “more compliant” if she received some sage advice from practitioners at the holistic center.

The discussion was left at that.

During a recent round of visits on the oncology floor, Allen, the chaplain-in-training, knocked lightly on patients’ doors before entering. He moved silently into their rooms and sat beside them, ignoring TVs blaring pop music or squeals from “The Price is Right.”

On this day, the patients included a Burmese man with nasal cancer who had requested time with a Buddhist chaplain. The patient appeared weighed down by the white sheets atop his slender frame. “You seem very tired. Do you feel bad today?” Allen asked the man, who requested that his name not be published. The patient nodded. He was too sick to eat, but he wanted to practice breathing exercises to relieve his pain.

He struggled to sit up in bed. Then he closed his eyes as Allen coached him in a soothing voice. “Take a nice, deep, cleansing breath,” Allen said. “Blow out all that toxin from your face, your nose, your eyes, so you can bring peace and calm to yourself.”

Next, Allen visited Victoria Exconde, who was facing breast cancer surgery. A Roman Catholic from the Philippines, Exconde broke down in tears as she discussed her condition and the difficulty of going through it without her late husband by her side.

The two then recited a Christian prayer together.

“Thank you, father,” Exconde said.

“You don’t have to call me father,” Allen replied good-naturedly as he got up to leave.

Supporters of the Zen chaplains program say the monks’ presence brings a calming influence to the often frenetic hospital floors, and that patients, for the most part, are open to them.

“I think a lot of it has to do with the fact that a lot of our patients don’t really know what a Buddhist monk does,” said Terry Altilio, a social worker in Beth Israel’s palliative-care department, which focuses on relieving suffering of seriously ill patients. “For a lot of patients, there’s a curiosity and an openness you don’t necessarily see with rabbis, priests, etc.”

The Zen chaplains do not limit their services to patients.

Koshin recently accompanied a Catholic priest to tend to a couple whose infant had died at the hospital, explaining that “the priest didn’t want to go alone because he’d never been with a dead child.”

During morning rounds, when medical teams gather to discuss their cases, the chaplains sit in. In the case of one 30-year-old Chinese man with cancer, Chodo advised that they needed to be careful because in Chinese culture, “you don’t normally discuss death in front of the patient.”

Once a week, Chodo visits the Robert Mapplethorpe Residential Treatment Facility, part of Beth Israel’s AIDS treatment program.

Most of the patients, whose harsh lives show in their tired eyes and bodies, have spent time in prison or on the streets.

But here they were, sitting in a dark room, chanting the lotus sutra while having their heads massaged. As Chodo’s soothing voice filled the room, their chatter gave way to dreamy murmurs.

“When I meditate, it takes me to some beautiful places, even though I’m from Brooklyn,” said Kevin, one of the center’s residents, ticking off his visions of paradise: Paris, Rio, Jamaica.

George, another resident, asked everyone to remember the 228 souls lost when an Air France jet vanished over the Atlantic Ocean. The crash was a reminder of how life can be cut short without warning, Chodo said, urging those around the table to be kinder to themselves each day — perhaps by having one less cigarette or doughnut, or making one less trip to Starbucks.

Then he cleared the room so he could meet privately with Rafael, an AIDS patient whose clothes hung from his once-buff frame. Rafael wept as he spoke of his fiancee in the Bronx, who no longer visited or returned his calls.

Chodo held his hand and simply listened, saying nothing.

After a few minutes, Rafael thanked Chodo and shuffled back to his room.

Spinal Shocks Ease Parkinson’s in Mice

March 20th, 2009

From:NewYorkTimes.com
By electrically stimulating the spinal cords of rodents, scientists have reversed some of the worst symptoms of Parkinson’s disease.

As long as a mild current flows up their spines and into their brains, the animals regain the ability to scamper around their cages, as if they were normal.

The therapy, described in Friday’s issue of the journal Science, is a potential alternative to direct stimulation, which requires risky and invasive surgery to implant electrodes deep in the brain, researchers said. Only 30 percent of severely impaired Parkinson’s patients qualify for the operation.

Spinal cord stimulation would be less invasive and inherently safer, and it would reduce the amount of drugs needed to treat the disease, said the report’s lead author, Dr. Miguel A. L. Nicolelis, a neuroscientist at Duke. Dr. Nicolelis added that the procedure was now being tested on monkeys, and “if it succeeds, human clinical trials could begin in the next few years.”

An expert on stimulation theories who was not involved in the research, Dr. Rodolfo Llinás, said the treatment “makes good sense,” but he added:

“How successfully it will translate to humans is an important issue. The human spinal cord is much more complex than the rodent counterpart, and long-term stimulation might result in nasty secondary effects.”

Dr. Llinás is chairman of neuroscience and physiology at the N.Y.U. School of Medicine.

Dr. Ali Rezai, a neurosurgeon and director of the Center for Neurological Restoration at the Cleveland Clinic, said spinal cord stimulation was “technically simple to do” and had been performed on tens of thousands of people to treat chronic pain, spasticity, stroke and other medical problems. The main side effect is a sense of vibration, like pins and needles, that never lets up.

The idea of using spinal cord stimulation to treat Parkinson’s disease, however, is entirely new, Dr. Rezai said, and he called it both “provocative” and “fascinating,” though further research was needed on how it would work in practice.

Parkinson’s disease results from a loss of cells that secrete dopamine, a brain chemical essential for normal movement. Patients develop tremors, rigid posture, impaired balance and an inability to initiate movement. In the United States, at least half a million people are believed to suffer from Parkinson’s disease, and about 50,000 new cases are reported each year.

The first line of treatment is L-dopa, a drug that restores dopamine but stops working over time. Direct brain stimulation seeks to ease symptoms by focusing on specific brain regions involved in dopamine transmission.

In the new treatment, animals whose brains were depleted of dopamine had tiny electrodes, the size of a fingernail, implanted on their spinal cords. Three seconds after a mild electrical stimulation began, they could move about normally.

The treatment was also effective when combined with L-dopa in further experiments; only two doses of L-dopa were needed to produce movement, compared with five doses when it was used by itself.

Spinal cord stimulation represents a “big conceptual change” in how to treat Parkinson’s disease, Dr. Nicolelis said. Rather than looking at where things happen in the brain, as in small regions missing dopamine, the approach focuses on when things happen, as in the dynamic firing patterns of large circuits of neurons. These circuits oscillate in harmony and underlie normal brain function.

Parkinson’s patients have abnormal low-frequency oscillations in the brain regions controlling movement, Dr. Nicolelis said. Stimulation of the topmost layer of the spinal cord, which conveys touch sensations to the brain, may work by disrupting these abnormal oscillations, restoring normal firing patterns across multiple brain structures involved in the control of voluntary movements.

Dr. Nicolelis added that more research was needed to determine whether other mechanisms might explain the therapy’s success in rodents

New Lab Evidence Suggests Preventive Effect Of Herbal Supplement In Prostate Cancer

March 8th, 2009

From sciencedaily.com
DHEA is a natural circulating hormone and the body’s production of it decreases with age. Men take DHEA as an over-the-counter supplement because it has been suggested that DHEA can reverse aging or have anabolic effects since it can be metabolized in the body to androgens. Increased consumption of dietary isoflavones is associated with a decreased risk of prostate cancer.

Red clover (Trifolium pretense) is one source of isoflavones. Both supplements may have hormonal effects in the prostate and little is known about the safety of these supplements.

In a recent report in Cancer Prevention Research, a journal of the American Association for Cancer Research, researchers report that DHEA levels can be manipulated in cells in the laboratory to understand its effects.

Julia Arnold, Ph.D., a staff scientist at the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health, said more research is necessary in an environment where men and women concerned about health problems tend to self-prescribe based on information they find on the Internet.

Towards this end, the NCCAM laboratory is studying signaling between human prostate cancer cells and their supporting stromal cells as they grow together in laboratory culture. “DHEA effects in the prostate tissues may depend on how these two cells types ‘talk to each other’ and further, it may be potentially harmful in tissues containing inflammation or with early cancer lesions because the cells can induce DHEA to become more androgenic,” said Arnold.

Combining DHEA with transforming growth factor beta-1 increased testosterone production in the stromal cells and prostate specific antigen protein secretion two to four-fold and gene expression up to 50-fold in the cancer cells. When these cell cultures were treated with red clover isoflavones, the androgenic effects of DHEA were reversed.

“Something is happening in the prostate tissue microenvironment that is illustrating a potential cancer prevention effect from this supplement,” said Arnold.

Red clover isoflavones may modify androgenic effects in the prostate but much more work in the laboratory and clinic is needed to validate these effects.

This sort of laboratory manipulation will allow scientists to understand the basic prostate biology as well as learn cellular and molecular mechanisms of over-the-counter supplements and other botanical or herbal agents. Arnold said NCCAM will continue to study DHEA with other supplements to determine any cancer preventive effects.

Researchers Find Safer Way to Produce Stem Cell Alternative

March 2nd, 2009

From washingtonpost.com
Scientists have developed what appears to be a safer way to create a promising alternative to embryonic stem cells, boosting hopes that such cells could sidestep the moral and political quagmire that has hindered the development of a new generation of cures.

The researchers produced the cells by using strands of genetic material, instead of potentially dangerous genetically engineered viruses, to coax skin cells into a state that appears biologically identical to embryonic stem cells.

“It’s a leap forward in the safe application of these cells,” said Andras Nagy of Mount Sinai Hospital in Toronto, who helped lead the international team of researchers that described the work in two papers being published online today by the journal Nature. “We expect this to have a massive impact on this field.”

In addition to the scientific implications, the work comes at a politically sensitive moment. Scientists are anxiously waiting for President Obama to follow through on his promise to lift restrictions on federal funding for research on human embryonic stem cells. Critics of such a move immediately pointed to the work as the latest evidence that the alternative cells make such research unnecessary.

“Stem cell research that requires destroying embryos is going the way of the Model T,” Richard M. Doerflinger of the U.S. Conference of Catholic Bishops said. “No administration that values science and medical progress over politics will want to divert funds now toward that increasingly obsolete and needlessly divisive approach.”

Scientists, however, while praising the work as a potentially important advance, said it remains crucial to work on both types of cells because it is far from clear which will turn out to be more useful.

“The point is, we don’t know yet what the end potential of either of these approaches will be,” said Mark A. Kay of Stanford University. “No one has cured any disease in people with any of these approaches yet. We don’t know enough yet to know which approach will be better.”

Because embryonic stem cells are believed capable of becoming any kind of tissue in the body, scientists believe they could eventually lead to treatments or even cures for a host of ailments, including heart disease, diabetes, and Alzheimer’s and Parkinson’s diseases. In 2001, President George W. Bush restricted federal funding for human embryonic stem cell research to prevent taxpayer money from encouraging the destruction of human embryos, which is necessary to obtain the cells.

The alternative cells, known as induced pluripotent stem cells, or iPS cells, appear to have many of the same characteristics as embryonic stem cells but are produced by activating genes in adult cells to “reprogram” them into a more primitive state, bypassing the moral, political and ethical issues surrounding embryonic cells. Until now, however, their use has been limited because the genetic manipulation required the use of viruses, raising concerns the cells could cause cancer if placed in a patient. That has triggered a race to develop alternative approaches.

“These viral insertions are quite dangerous,” Nagy said.

In the new work, Nagy and his colleagues in Toronto and at the University of Edinburgh in Scotland instead used a sequence of DNA known as a transposon, which can insert itself into the genetic machinery of a cell. In this case, the researchers used a transposon called “piggyBac” to carry four genes that can transform mouse and human embryonic skin cells into iPS cells. After the conversion took place, the researchers removed the added DNA from the transformed cells using a specific enzyme.

“PiggyBac carries the four genes into the cells and reprograms the cells into stem cells. After they have reprogrammed the cells, they are no longer required, and in fact they are dangerous,” Nagy said. “After they do their job they can be removed seamlessly, with no trace left behind. The ability for seamless removal opens up a huge possibility.”

A series of tests showed that the transformed cells had many of the properties of embryonic stem cells, Nagy said.

The researchers did their initial work on skin cells from embryos but say the approach should work just as efficiently in adult cells, and they plan to start those experiments.

“We do not expect that adult cells would behave significantly differently than the ones we are using currently,” Nagy said.

In addition to producing safer cell lines that would be less likely to cause cancer in patients, the advance will enable many more scientists to begin working on such cells because they require no expertise or special laboratories necessary for working with viruses, he said.

“This opens up the possibility of working in this field for laboratories that don’t have viral labs attached to them. A much larger number of laboratories will be able to push this field forward,” Nagy said.

Other researchers praised the work.

“It’s very significant,” said George Q. Daley, a stem cell researcher at Children’s Hospital in Boston. “I think it’s a major step forward in realizing the value of these cells for medical research.”

“It’s very exciting work,” agreed Robert Lanza, a stem cell researcher at Advanced Cell Technology in Worcester, Mass. “With the new work, we’re only a hair’s breadth away from the biggest prize in regenerative medicine — a way to create patient-specific cells that are safe enough to use clinically.”

Kay agreed that the work is promising but cautioned that much more research will be needed to prove that cells produced this way are safe. Many scientists are working on other approaches that may turn out to be safer and more efficient, he said.

“This is a step forward. The research is heading in the right direction. But there still may be room for improvement,” he said.

Fighting a cold? Try a little sunshine

February 25th, 2009

From denverpost.com
Rethink orange juice and lozenges infused with vitamin C for staving off colds and the flu. Perhaps the answer is in the sunshine.

Vitamin D — which can be had for free from the sun’s rays — boosts immunity, according to the largest and most nationally representative study so far on the subject.

“The major source of vitamin D is sunlight,” said Dr. Adit Ginde, a University of Colorado-Denver surgery professor and lead author of the study, done in conjunction with Harvard Medical School. “That’s one potential reason that we have so many respiratory infections in the winter.”

The study examined vitamin D levels in the blood of 19,000 people. Those with the lowest levels of the vitamin were about 40 percent more likely to have had a recent respiratory infection.

Still, the study authors said clinical trials must confirm their results before vitamin D is recommended to prevent colds and flu.

Vitamin C has long been associated with boosting immunity against upper-respiratory infections, including colds and flu. But little scientific evidence actually supports that, doctors said.

“It gets out in the lay public and just gets self-perpetuated,” Ginde said. “It’s one of those things that people say it doesn’t hurt to take more. But the science surrounding Vitamin D has really expanded over the last couple of years.”