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Virus Associated With Chronic Fatigue Syndrome

October 15th, 2009

From WashingtonPost.com:

Scientists have found evidence that a virus may play a role in chronic fatigue syndrome.

Vincent C. Lombardi of the Whittemore Peterson Institute in Reno, Nev., and scientists elsewhere studied 101 patients with chronic fatigue syndrome, a baffling, debilitating and controversial condition that affects an estimated 17 million people worldwide. They discovered that 68 of the patients — 67 percent — had a virus in their blood known as the xenotropic murine leukemia virus-related virus or XMRV. Only eight of 218 similar subjects who did not have chronic fatigue syndrome — 3.7 percent — had the virus in their blood, the researchers report in a paper published online Thursday by the journal Science.

Further studies showed that the virus is indeed infectious, and can “provoke” the immune system to respond.

The researchers cautioned that the findings far from prove that the virus causes chronic fatigue. It may be just part of the picture. But they suggest that the virus may at least contribute to the development of the disorder. This isn’t the first time a virus has been associated with the condition. Previous research has suggested that some herpes viruses and other viruses may also play a role.

In an article accompanying the research, John Coffin of Tufts University in Boston and Jonathan Stoye of the National Institute for Medical Research in London agreed. They noted that there are many unanswered questions about the virus, including how it is transmitted. But if the findings are representative of what’s going on in the general public, perhaps 10 million Americans and hundreds of millions of people worldwide might be infected with the virus, which could turn out to be playing a role in a variety of diseases. The virus previously was found in some patients with prostate cancer.

Chronic Fatigue Syndrome Linked to Hormone

January 28th, 2008

From WebMD

- Chronic fatigue syndrome may be linked to the stress hormone cortisol, at least in women, according to a new study.

The study shows that women with chronic fatigue syndrome had lower cortisol levels in the morning, compared with healthy women.

The study included 185 Georgia adults, 75 of whom had chronic fatigue syndrome. Those patients had fatigue lasting at least six months with no known cause and accompanied by at least four other symptoms, such as muscle pain or memory problems.

Participants provided saliva samples taken as soon as they woke up, and again 30 minutes and an hour later. The CDC’s William Reeves, MD, and colleagues measured cortisol levels in the saliva samples.

Chronic fatigue syndrome was associated with lower morning cortisol levels among women, but not among men. Morning cortisol levels were similar for men with and without chronic fatigue syndrome.

The study doesn’t prove that low morning levels of cortisol cause women’s chronic fatigue syndrome. The researchers don’t know which came first — low morning cortisol levels or chronic fatigue syndrome — but their findings may be a clue for researchers