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September 17, 2012
by David Perlmutter, MD, FACN, ABIHM
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by David Perlmutter, MD, FACN, ABIHM &
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Alpha Lipoic acid explored as an anti-aging compound

December 21st, 2010

From Biosingularity

Researchers said today they have identified the mechanism of action of lipoic acid, a remarkable compound that in animal experiments appears to slow down the process of aging, improve blood flow, enhance immune function and perform many other functions.

The findings, discussed at the Diet and Optimum Health conference sponsored by the Linus Pauling Institute at Oregon State University, shed light on how this micronutrient might perform such a wide range of beneficial functions.

The evidence suggests that lipoic acid is actually a low-level stressor that turns on the basic cellular defenses of the body, including some of those that naturally decline with age, said Tory Hagen, an LPI researcher and associate professor of biochemistry and biophysics at OSU. In particular, it tends to restore levels of glutathione, a protective antioxidant and detoxification compound, to those of a young animal. It also acts as a strong anti-inflammatory agent, which is relevant to many degenerative diseases.

Researchers at LPI are studying vitamins, dietary approaches and micronutrients that may be implicated in the aging or degenerative disease process, and say that lipoic acid appears to be one of those with the most compelling promise. Its normally found at low levels in green leafy vegetables, but can also be taken as a supplement.

According to Hagen, research on the natural processes of aging, and steps that could slow it or improve health until near the end of life, are of growing importance.

Were coming into the middle of an aging epidemic in the country, he said. In a short time more than 70 million Americans will be over 65. This is partly because of the Baby Boom, but also people are living longer, being saved with antibiotics and other medical treatments. In any case, it will be an unprecedented number of elderly people in this nation.

The goal of LPI research, Hagen said, is to address issues of healthspan, not just lifespan

meaning the ability to live a long life with comparatively good health and vigor, free of degenerative disease, until very near death. The best mechanisms to accomplish that, scientists say, have everything to do with diet, exercise, healthy lifestyle habits and micronutrient intake.

At the moment, Hagen said, thats not the way things appear to be headed

diabetes is skyrocketing, about 50 percent of people over 65 have high blood pressure, heart disease often leads to permanent disability, and almost half of the elderly people in America have malnutrition that is easily preventable.

No single intervention can address all of these issues, Hagen said, but one that scientists keep coming back to is lipoic acid.

Our studies have shown that mice supplemented with lipoic acid have a cognitive ability, behavior, and genetic expression of almost 100 detoxification and antioxidant genes that are comparable to that of young animals, Hagen said. They arent just living longer, they are living better

and thats the goal were after.

What the OSU researchers now believe is that the role of lipoic acid is not so much a direct one to benefit cells, but rather an indirect aid that kick starts declining function in cells and helps them recover the functions that came more easily and naturally in young animals.

In various effects, lipoic acid appears to help restore a cellular signaling process that tends to break down in older blood vessels. It reduces mitochondrial decay in cells, which is closely linked to the symptoms of aging. With age, glutathione levels naturally decline, making older animals more susceptible to both free radicals and other environmental toxins

but lipoic acid can restore glutathione function to near normal. And the expression and function of other genes seems to come back to life.

We never really expected such a surprising range of benefits from one compound, Hagen said. This is really unprecedented, and were pretty excited about it.

Many other presentations have been made at this conference on the role of diet, lifestyle and micronutrients in health and degenerative disease, including cancer, heart disease, neurological diseases and aging

Dr. Perlmutter’s comment:

This is supportive of our longstanding recommendation of lipoic acid in our programs geared at preserving and enhancing brain function. NeuroActives BrainSustain

Lifelong Exercising Yields Sensational Results

September 22nd, 2010

From ScienceDaily.com:

Senior active skiers have twice the oxygen-uptake capacity of seniors who do not exercise. This is shown in new research at Mid Sweden University.

“The findings show that humans have a great potential to maintain a high level of physical work capacity and thereby better quality of life even at advanced ages,” says Per Tesch, professor of sports science.
A year ago Mid Sweden University and the Karolinska Institute launched a study of seniors who are still active skiers. The study attracted a great deal of attention in the media in connection with testing and experiments in Östersund. Some of Sweden’s skiing icons, now more than 90 years old, took part.
Now the results of the study are being presented. They show that the maximum capacity for oxygen uptake is twice as great among active senior men compared with men who do not exercise. The results for the active seniors are comparable to values for men who are 40-50 years younger but do not exercise to improve their stamina. Analyses of muscle samples at the molecular and cell level reveal a profile similar to what is found in younger men.
“The high values for maximum oxygen-uptake capacity that we have measured have never been reported before in a population of men of advanced age,” says Per Tesch.
The findings from the study will be presented at the American College of Sports Medicine: Integrative Physiology of Exercise in Miami Beach this week.
The study is part of a larger collaborative project co-directed by physiologist Per Tesch, professor of sports science at Mid Sweden University and Scott Trappe, professor of sports physiology at Ball State University, Muncie, Indiana, USA. The ultimate purpose of the project is to study how musculature, the circulatory apparatus, and performance are affected by lifelong exercising well into senior years.

How You Think About Your Age May Affect How You Age

June 5th, 2010

From USNews.com:

The saying “You’re only as old as you feel” really seems to resonate with older adults, according to research from Purdue University.

“How old you are matters, but beyond that it’s your interpretation that has far-reaching implications for the process of aging,” said Markus H. Schafer, a doctoral student in sociology and gerontology who led the study. “So, if you feel old beyond your own chronological years you are probably going to experience a lot of the downsides that we associate with aging.

“But if you are older and maintain a sense of being younger, then that gives you an edge in maintaining a lot of the abilities you prize.”

Schafer and co-author Tetyana P. Shippee, a Purdue graduate who is a research associate at Purdue’s Center on Aging and the Life Course, compared people’s chronological age and their subjective age to determine which one has a greater influence on cognitive abilities during older adulthood. Nearly 500 people ages 55-74 were surveyed about aging in 1995 and 2005 as part of the National Survey of Midlife Development in the United States.

In 1995, when people were asked what age do you feel most of the time, the majority identified with being 12 years younger than they actually were.

“We found that these people who felt young for their age were more likely to have greater confidence about their cognitive abilities a decade later,” Schafer said. “Yes, chronological age was important, but the subjective age had a stronger effect.

“What we are not sure about is what comes first. Does a person’s wellness and happiness affect their cognitive abilities or does a person’s cognitive ability contribute to their sense of wellness. We are planning to address this in a future study.”

Schafer also said that the current study’s findings have both positive and negative implications.

“There is a tremendous emphasis on being youthful in our society and that can have a negative effect for people,” Schafer said. “People want to feel younger, and so when they do inevitably age they can lose a lot of confidence in their cognitive abilities.

“But on the other hand, because there is such a desire in America to stay young, there may be benefits of trying to maintain a sense of youthfulness by keeping up with new trends and activities that feel invigorating. Learning new technologies is one way people can continue to improve their cognitive abilities. It will be interesting to see how, or if, these cultural norms shift as the Baby Boomer generation ages.”

Other studies have shown that women are prone to aging stereotypes, so Schafer expected to see that women who felt older about themselves would have less confidence in their cognitive abilities.

“There is a slight difference between men and women, but it’s not as pronounced as we expected,” Schafer said. “This was surprising because of the emphasis on physical attractiveness and youth that is often disproportionately placed on women.”

Schafer also is studying how stressful events, such as family members’ health issues, affect aging, as well as how happiness and aging relate

Mexico’s health care lures Americans

December 18th, 2009

From USAToday:

It sounds almost too good to be true: a health care plan with no limits, no deductibles, free medicines, tests, X-rays, eyeglasses, even dental work — all for a flat fee of $250 or less a year.
To get it, you just have to move to Mexico.

As the United States debates an overhaul of its health care system, thousands of American retirees in Mexico have quietly found a solution of their own, signing up for the health care plan run by the Mexican Social Security Institute.

The system has flaws, the facilities aren’t cutting-edge, and the deal may not last long because the Mexican government said in a recent report that it is “notorious” for losing money. But for now, retirees say they’re getting a bargain.

“It was one of the primary reasons I moved here,” said Judy Harvey of Prescott Valley, who now lives in Alamos, Sonora. “I couldn’t afford health care in the United States. … To me, this is the best system that there is.”

It’s unclear how many Americans use IMSS, but with between 40,000 and 80,000 U.S. retirees living in Mexico, the number probably runs “well into the thousands,” said David Warner, a public policy professor at the University of Texas.

“They take very good care of us,” said Jessica Moyal, 59, of Hollywood, Fla., who now lives in San Miguel de Allende, Mexico, a popular retirement enclave for Americans.

The IMSS plan is primarily designed to support Mexican taxpayers who have been paying into the system for decades, and officials say they don’t want to be overrun by bargain-hunting foreigners.

“If they started flooding down here for this, it wouldn’t be sustainable,” said Javier Lopez Ortiz, IMSS director in San Miguel de Allende.

Pre-existing conditions aren’t covered for the first two years, and some newer medicines and implants are not free. IMSS hospitals don’t have frills such as televisions or in-room phones, and they often require patients to bring family members to help with bathing and other non-medical tasks. Most doctors and nurses speak only Spanish, and Mexico’s overloaded court system doesn’t provide much recourse if something goes wrong.

But the medical care doesn’t cost a dime after paying the annual fee, and it is usually good, retirees and health experts say. Warner said most American retirees enroll in IMSS as a form of cheap insurance against medical emergencies, while using private doctors or traveling back to the USA for less urgent care. Medicare, the U.S. insurance plan for retirees, cannot be used outside the United States.

Program prompts relocation

The program has helped people such as Ron and Jemmy Miller of Shawano, Wis. They decided to retire early, but knew affording health care was going to be a problem.

Ron was a self-employed contractor, and Jemmy was a loan officer at a bank. At ages 61 and 52, respectively, they were too young to qualify for Medicare, but too old to risk not having health insurance.

“We knew that we couldn’t retire without Medicare,” Jemmy Miller said. “We’re pretty much in Mexico now because we can’t afford health care in the States.”

The couple learned about IMSS from Mexico guidebooks and the Internet. They moved to the central city of Irapuato in 2006, got residency visas as foreign retirees, and then enrolled in IMSS.

The IMSS system is similar to an HMO in the United States, Jemmy Miller said. Patients are assigned a primary care physician and given a passport-size ID booklet that includes records of appointments. The doctor can refer patients to specialists, a bigger hospital or one of the IMSS specialty hospitals in cities such as Guadalajara or Mexico City.

In 2007, Ron Miller got appendicitis and had emergency surgery at the local IMSS hospital. He was in the hospital for about a week and had a double room to himself. The food was good, the nurses were attentive, and doctors stopped by three or four times a day to check on him, he said. At the end of it all, there was no bill, just an entry in the ID booklet.

The Millers may soon move back to the United States, but Jemmy Miller said they want to try to maintain the IMSS coverage. “If something big really comes up, we’d probably come back to Mexico,” she said.

Different levels of care offered

IMSS is one of several public health systems in Mexico, each with its own network of hospitals and clinics. The program, which was founded in 1943, is funded by a combination of payroll deductions, employer contributions and government funds. It covers 50.8 million workers.

IMSS facilities are a step up from the state hospitals, but not as advanced as Mexico’s private hospitals, which are often world-class, said Curtis Page, a Tempe, Ariz., doctor and co-author of a book about health care in Mexico.

Most patients seem grateful nonetheless. When Michael Kirkpatrick, 63, of Austin, fell off his motorcycle near his home in San Miguel de Allende, IMSS surgeons gave him a stainless-steel artificial hip.

There was no physical rehabilitation after the surgery, just a checkup a few weeks later.

“There was not the kind of follow-through and therapy that you would expect if you were doing this in the first world,” Kirkpatrick said. “But it was satisfactory. The hip feels good.”

Bob Story, 75, of St. Louis, had prostate-reduction surgery at an IMSS hospital in Mazatlán and discovered that patients were expected to bring their own pillows. It was a small price to pay, he said, for a surgery that would have cost thousands of dollars back home.

“I would say it’s better than any health plan I’ve had in the States,” he said

Alcohol and the elderly

September 22nd, 2009

Studies point to benefits in a drink a day, but many caveats remain

From ChicagoTribune.com:

Seniors may help ward off dementia by indulging in a beer or a glass of wine daily, new studies suggest.

But there’s an important caveat: The findings apply to healthy people, not those with mild cognitive impairments or other chronic medical conditions.

The studies add to scientific literature documenting potential health benefits associated with moderate alcohol consumption. For seniors, benefits include a reduced risk of dementia, heart disease, diabetes, disability and stroke.

It’s well known that moderate drinkers tend to get more exercise, weigh less and be healthier overall. Though researchers try to adjust for those and other differences they may fail to do so sufficiently, said Dr. Alison Moore, assistant professor of medicine and psychiatry at UCLA’s David Geffen School of Medicine.

The newest research comes out of Wake Forest University and was presented this summer at the International Conference on Alzheimer’s Disease in Vienna. The report looked at people 75 and older who had 8 to 14 drinks a week. Those without memory problems at the start of the six-year study were 37 percent less likely to develop dementia than people who didn’t drink at all.

What could account for the result? Research suggests that moderate alcohol consumption prevents heart disease and perhaps stroke as well by keeping blood clots from forming, raising so-called “good” cholesterol, and making blood less viscous.

“Things that are good for your heart are good for your brain,” said lead researcher Dr. Kaycee Sink, a geriatrician at Wake Forest.

A July study in The American Journal of Psychiatry confirms the positive finding. It analyzed 15 previous studies involving more than 28,000 individuals over the age of 60 and discovered that men who drank moderately were 45 percent less likely to develop dementia. For women, the reduction in risk was 27 percent.

But those beneficial effects don’t apply to everyone. In the Wake Forest study, older adults with mild cognitive impairments fared worse when they consumed any amount of alcohol. Also, heavy drinkers were almost twice as likely to develop dementia.

These exceptions don’t come as a surprise. Alcohol is known to have a sedative effect, potentially impairing a senior’s mental status, balance and coordination and heightening an older adult’s confusion and susceptibility to falls and accidents, experts note.

Also, alcohol interacts poorly with many medications routinely taken by older people, sometimes lessening their effectiveness. A higher risk of some kinds of cancer is also associated with alcohol, complicating the calculation of potential benefits versus harm. Then, there’s the potential for addiction: As many as 11 percent of seniors admitted to hospitals exhibit symptoms of alcoholism, according to government data.

Biologically, seniors metabolize alcohol more slowly than younger adults and have less tolerance to liquor. Given the same number of drinks, an older adult will have higher blood alcohol levels than someone who’s middle-age, according to Samir Zakhari, director of the division of metabolism and health effects at the National Institute on Alcohol Abuse and Alcoholism.

On a practical level, that means seniors need to be more careful after having a drink or two, said Sarah Jo Nixon, chief of the division of addiction research at the University of Florida. Older adults should wait at least an hour before driving, she said.

Recommendations call for older men to have no more than two drinks a day and for older women to have no more than one drink a day — if they already have the habit. It doesn’t make sense for seniors to start drinking if they’ve abstained during middle age, in part because it probably takes many years for potential benefits to accrue, experts say.

“Basic clinical advice is, ‘If you don’t drink, don’t start, and if you do drink, watch how much you drink,’ ” said Dr. Gary Kennedy, director of geriatric psychiatry at Montefiore Medical Center in New York.