Comments on: Antioxidants Reduce Alzheimer’s Risk http://www.vanguardneurologist.com/alzheimer%e2%80%99s-drugs-a-waste-of-money/ A Blog by David Perlmutter, MD, FACN, ABIHM Mon, 12 Jul 2010 14:39:43 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: military u.s http://www.vanguardneurologist.com/alzheimer%e2%80%99s-drugs-a-waste-of-money/comment-page-1/#comment-161 military u.s Wed, 14 Mar 2007 07:13:19 +0000 http://renegadeneurologist.com/?p=6#comment-161 <strong>iraqi security forces national military u s ...</strong> beautiful online information center. greatest workÂ… thanks ... iraqi security forces national military u s
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]]> By: Dr. Perlmutter http://www.vanguardneurologist.com/alzheimer%e2%80%99s-drugs-a-waste-of-money/comment-page-1/#comment-69 Dr. Perlmutter Thu, 08 Feb 2007 04:58:37 +0000 http://renegadeneurologist.com/?p=6#comment-69 These are excellent points. My interest is in the role of glutathione and it's important role as a cerebral antioxidant. Specifically, glutathione peroxidase is a selenocysteine-dependent enzyme which is thus dependent upon adequate selenium for appropriate function. <a href="http://www.medscape.com/medline/abstract/15487768">Effects of dietary selenium on glutathione peroxidase and thioredoxin reductase activity and recovery from cardiac ischemia-r...</a>Please see our ongoing research with reference to glutathione under the Perlmutter Brain Foundation posting. These are excellent points. My interest is in the role of glutathione and it’s important role as a cerebral antioxidant. Specifically, glutathione peroxidase is a selenocysteine-dependent enzyme which is thus dependent upon adequate selenium for appropriate function. Effects of dietary selenium on glutathione peroxidase and thioredoxin reductase activity and recovery from cardiac ischemia-r…Please see our ongoing research with reference to glutathione under the Perlmutter Brain Foundation posting.

]]> By: mmlevy http://www.vanguardneurologist.com/alzheimer%e2%80%99s-drugs-a-waste-of-money/comment-page-1/#comment-66 mmlevy Thu, 08 Feb 2007 02:03:53 +0000 http://renegadeneurologist.com/?p=6#comment-66 Dr. Peerlmutter, I think the fact that statins result in interruption of isopentylation of selenocysteine-tRNA, and that selenocysteine-tRNA is responsible for the expression of all selenoproteins thought to provide the functions of selenium, I find the following important and relevant to this discussion. have you an opinion concerning selenium functions, statins and neurodegenerative diseases? thanks Decreases in Plasma Selenium Linked to Cognitive Decline in Elderly Information from Industry NEW YORK (Reuters Health) Feb 01 - Results of a longitudinal cohort study suggest that selenium status decreases with age and may contribute to declines in neuropsychological functions among the elderly. "Because brain oxidative stress is a cause of cognitive impairment, selenium, which is an antioxidant, may protect against cognitive decline," Dr. N. Tasnime Akbaraly, of Universite Montpellier, France, and colleagues write in the January issue of Epidemiology. The researchers recruited 1389 community-dwelling French subjects during 1991 to 1993 for a 9-year longitudinal study with 6 waves of follow-up. The participants ranged in age from 60 to 71 years at baseline when they provided information on sociodemographic factors and were tested to assess cognitive function. Serum selenium levels were determined using electrothermal atomic absorption spectrometry. The baseline mean plasma selenium level was 1.09 mol/L, and a decrease was observed over the entire follow-up period. Mean levels of selenium declined -0.055 mol/L at 2 years and -0.096 mol/L at 9 years. The investigators report that cognitive decline was associated with decreases of plasma selenium over time after controlling for potential confounders. Among subjects whose plasma selenium levels decreased, there was a higher probability of cognitive decline with greater decreases of plasma selenium. For those who had an increase in their levels of plasma selenium, greater cognitive decline was observed in those with the smallest selenium increases. No association was found between short-term selenium change and cognitive changes. "Our results, together with information on involvement of selenoproteins in brain functions, support possible relationships between selenium status and neuropsychologic functions in aging people," Dr. Akbaraly's team concludes. "In this context, the preventive effect of selenium supplementation at a nutritional level needs to be evaluated with large-scale studies," they suggest. "This dynamic approach could shed new lights on the potential benefits of supplementation." Epidemiology 2007;18:52-58. Dr. Peerlmutter, I think the fact that statins result in interruption of isopentylation of selenocysteine-tRNA, and that selenocysteine-tRNA is responsible for the expression of all selenoproteins thought to provide the functions of selenium, I find the following important and relevant to this discussion. have you an opinion concerning selenium functions, statins and neurodegenerative diseases? thanks

Decreases in Plasma Selenium Linked to Cognitive Decline in Elderly

Information from Industry

NEW YORK (Reuters Health) Feb 01 – Results of a longitudinal cohort study suggest that selenium status decreases with age and may contribute to declines in neuropsychological functions among the elderly.

“Because brain oxidative stress is a cause of cognitive impairment, selenium, which is an antioxidant, may protect against cognitive decline,” Dr. N. Tasnime Akbaraly, of Universite Montpellier, France, and colleagues write in the January issue of Epidemiology.

The researchers recruited 1389 community-dwelling French subjects during 1991 to 1993 for a 9-year longitudinal study with 6 waves of follow-up. The participants ranged in age from 60 to 71 years at baseline when they provided information on sociodemographic factors and were tested to assess cognitive function.

Serum selenium levels were determined using electrothermal atomic absorption spectrometry. The baseline mean plasma selenium level was 1.09 mol/L, and a decrease was observed over the entire follow-up period. Mean levels of selenium declined -0.055 mol/L at 2 years and -0.096 mol/L at 9 years.

The investigators report that cognitive decline was associated with decreases of plasma selenium over time after controlling for potential confounders.

Among subjects whose plasma selenium levels decreased, there was a higher probability of cognitive decline with greater decreases of plasma selenium. For those who had an increase in their levels of plasma selenium, greater cognitive decline was observed in those with the smallest selenium increases. No association was found between short-term selenium change and cognitive changes.

“Our results, together with information on involvement of selenoproteins in brain functions, support possible relationships between selenium status and neuropsychologic functions in aging people,” Dr. Akbaraly’s team concludes.

“In this context, the preventive effect of selenium supplementation at a nutritional level needs to be evaluated with large-scale studies,” they suggest. “This dynamic approach could shed new lights on the potential benefits of supplementation.”

Epidemiology 2007;18:52-58.

]]> By: Dr. Perlmutter http://www.vanguardneurologist.com/alzheimer%e2%80%99s-drugs-a-waste-of-money/comment-page-1/#comment-10 Dr. Perlmutter Thu, 25 Jan 2007 20:16:47 +0000 http://renegadeneurologist.com/?p=6#comment-10 Good point. Here's what researchers in Israel report: Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological-pharmacological actions beneficial to human health. Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic. These observations are in line with the current view that polyphenolic dietary supplementation may have an impact on cognitive deficits in individuals of advanced age. As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. J Nutr Biochem. 2004 Sep;15(9):506-16 Good point. Here’s what researchers in Israel report:
Tea consumption is varying its status from a mere ancient beverage and a lifestyle habit, to a nutrient endowed with possible prospective neurobiological-pharmacological actions beneficial to human health. Accumulating evidence suggest that oxidative stress resulting in reactive oxygen species generation and inflammation play a pivotal role in neurodegenerative diseases, supporting the implementation of radical scavengers, transition metal (e.g., iron and copper) chelators, and nonvitamin natural antioxidant polyphenols in the clinic. These observations are in line with the current view that polyphenolic dietary supplementation may have an impact on cognitive deficits in individuals of advanced age. As a consequence, green tea polyphenols are now being considered as therapeutic agents in well controlled epidemiological studies, aimed to alter brain aging processes and to serve as possible neuroprotective agents in progressive neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases.
J Nutr Biochem. 2004 Sep;15(9):506-16

]]> By: Lise Rein http://www.vanguardneurologist.com/alzheimer%e2%80%99s-drugs-a-waste-of-money/comment-page-1/#comment-4 Lise Rein Sat, 13 Jan 2007 23:40:39 +0000 http://renegadeneurologist.com/?p=6#comment-4 What about anti-oxidants like polyphenols found in green tea? What about anti-oxidants like polyphenols found in green tea?

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